PUBLICATIONS
Scientific collaboration network between Tarling, Vallim, and the broader scientific community.
2025
Panzitt K, Jungwirth E, Vosko LE, Madreiter-Sokolowski CT, Madl T, Tawfik I, Habisch H, Krstic J, Prokesch A, Karitnig R, Sucher R, Erdogan CY, de Aguiar Vallim TQ, Trauner M, Fickert P, Al-Dury S, Molinaro A, Moore DD, Thallinger GG, Marschall HU, Wagner M. FXR adapts hepatic mitochondrial function to increased substrate oxidation in patients with obesity. Sci Transl Med. 2025 Aug 13;17(811):eadn4558. doi: 10.1126/scitranslmed.adn4558. Epub 2025 Aug 13. PMID: 40802742.
Bae H, Jung S, Le J, Tamburini I, Kim J, Wang E, Song WS, Choi W, Jang KH, Kang T, Lopez ML, Ramirez C, Mohanty I, Kelly ME, Kim J, Kim R, Park SH, Baek J, Mendez B, Petrus P, de Aguiar Vallim TQ, Nicholas DA, Smith Q, Lee G, Seldin M, Jang C. Cross-organ metabolite production and consumption in healthy and atherogenic conditions. Cell. 2025 Aug 7;188(16):4441-4455.e16. doi: 10.1016/j.cell.2025.05.001. Epub 2025 May 27. PMID: 40436017; PMCID: PMC12335369.
Schmidt HM, Tarling EJ, de Aguiar Vallim TQ. A molecular tango between chromatin and metabolites orchestrates a feedback switch for alcohol consumption. Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2512733122. doi: 10.1073/pnas.2512733122. Epub 2025 Jun 30. PMID: 40587807; PMCID: PMC12260555.
Zhou Z, Moore TM, Strumwasser AR, Ribas V, Iwasaki H, Morrow N, Ma A, Tran PH, Wanagat J, de Aguiar Vallim TQ, Clifford B, Zhang Z, Sallam T, Parks BW, Reue K, Shirihai O, Acin-Perez R, Morselli M, Pellegrini M, Mahata SK, Norheim F, Zhou M, Seldin MM, Lusis AJ, Lee CC, Goodarzi MO, Rotter JI, Hansen JR, Drucker B, Sagendorf TJ, Adkins JN, Sanford JA, DeMayo FJ, Hewitt SC, Korach KS, Hevener AL. Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males. Cell Rep Med. 2025 May 20;6(5):102116. doi: 10.1016/j.xcrm.2025.102116. Epub 2025 May 5. PMID: 40328250; PMCID: PMC12147913.
Little I, Bersie S, Redente EF, McCubbrey AL, Tarling EJ. Alveolar macrophages: guardians of the alveolar lipid galaxy. Curr Opin Lipidol. 2025 Jun 1;36(3):153-162. doi: 10.1097/MOL.0000000000000987. Epub 2025 Apr 2. PMID: 40183504; PMCID: PMC12043416.
Schmidt HM, Jarrett KE, de Aguiar Vallim TQ, Tarling EJ. Pathways and Molecular Mechanisms Governing LDL Receptor Regulation. Circ Res. 2025 Apr 11;136(8):902-919. doi: 10.1161/CIRCRESAHA.124.323578. Epub 2025 Apr 10. PMID: 40208925; PMCID: PMC11989972.
Ayala I, Hebbale SK, Mononen J, Brearley-Sholto MC, Shannon CE, Valdez I, Fourcaudot M, Bakewell TM, Zagorska A, Romero G, Asmis M, Musa FA, Sily JT, Smelter AA, Hinostroza EA, Freitas Lima LC, de Aguiar Vallim TQ, Heikkinen S, Norton L. The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis. Nat Commun. 2025 Apr 10;16(1):3408. doi: 10.1038/s41467-025-58714-5. PMID: 40210847; PMCID: PMC11986045.
2024
Rauckhorst AJ, Sheldon RD, Pape DJ, Ahmed A, Falls-Hubert KC, Merrill RA, Brown RF, Deshmukh K, de Aguiar Vallim TQ, Deja S, Burgess SC, Taylor EB. A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones. Cell Metab. 2025 Jan 7;37(1):255-273.e6. doi: 10.1016/j.cmet.2024.10.013. Epub 2024 Oct 28. PMID: 39471817; PMCID: PMC11856365.
O'Callaghan M, Tarling EJ, Bridges JP, Redente EF, Byrne AJ, Keane MP, McCarthy C. Reexamining the Role of Pulmonary Lipids in the Pathogenesis of Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2024 Oct;71(4):407-419. doi: 10.1165/rcmb.2024-0124PS. PMID: 38820234.
Hong SG, Ashby JW, Kennelly JP, Wu M, Steel M, Chattopadhyay E, Foreman R, Tontonoz P, Tarling EJ, Turowski P, Gallagher-Jones M, Mack JJ. Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation. J Clin Invest. 2024 May 21; 134(13):e175057. doi: 10.1172/JCI175057. PMID: 38771648; PMCID: PMC11213468.
Bendixen SM, Jakobsgaard PR, Hansen D, Hejn KH, Terkelsen MK, Bjerre FA, Thulesen AP, Eriksen NG, Hallenborg P, Geng Y, Dam TV, Larsen FT, Wernberg CW, Vijayathurai J, Scott EAH, Marcher AB, Detlefsen S, Grøntved L, Dimke H, Berdeaux R, de Aguiar Vallim TQ, Olinga P, Lauridsen MM, Krag A, Blagoev B, Ravnskjaer K. Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module. J Hepatol. 2024 Mar; 80(3):467-481. doi: 10.1016/j.jhep.2023.11.001. PMID: 37972658.
Lee E, Williams KJ, McCarthy C, Bridges JP, Redente EF, de Aguiar Vallim TQ, Barrington RA, Wang T, Tarling EJ. Alveolar macrophage lipid burden correlates with clinical improvement in patients with pulmonary alveolar proteinosis. J Lipid Res. 2024 Feb; 65(2):100496. doi: 10.1016/j.jlr.100496. PMID: 38185217; PMCID: PMC10844116.
Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ. Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. J Lipid Res. 2024 Feb; 65(2):100434. doi: 10.1016/j.jlr.2023.100434. PMID: 37640283; PMCID: PMC10839691.
2023
Sunshine HL, Cicchetto AC, Kaczor-Urbanowicz KE, Ma F, Pi D, Symons C, Turner M, Shukla V, Christofk HR, de Aguiar Vallim TQ, Iruela-Arispe ML. Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins. Cell Rep. 2024 Jan 23;43(1):113627. doi: 10.1016/j.celrep.2023.113627. Epub 2023 Dec 28. PMID: 38157296; PMCID: PMC10884959.
O'Callaghan M, Duignan J, Tarling EJ, Waters DK, McStay M, O'Carroll O, Bridges JP, Redente EF, Franciosi AN, McGrath EE, Butler MW, Dodd JD, Fabre A, Murphy DJ, Keane MP, McCarthy C. Analysis of tissue lipidomics and computed tomography pulmonary fat attenuation volume (CTPFAV) in idiopathic pulmonary fibrosis. Respirology. 2023 Nov; 28(11):1043-1052. doi: 10.1111/resp.14582. PMID: 37642207.
Cicchetto AC, Jacobson EC, Sunshine H, Wilde BR, Krall AS, Jarrett KE, Sedgeman L, Turner M, Plath K, Iruela-Arispe ML, de Aguiar Vallim TQ, Christofk HR. ZFP36-mediated mRNA decay regulates metabolism. Cell Rep. 2023 May 30; 42(5):112411. doi: 10.1016/j.celrep.2023.112411. PMID: 37086408; PMCID: PMC10332406.
Clifford BL, Jarrett KE, Cheng J, Cheng A, Seldin M, Morand P, Lee R, Chen M, Baldan A, de Aguiar Vallim TQ, Tarling EJ. RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. Circ Res. 2023 Mar 31;132(7):849-863. doi: 10.1161/CIRCRESAHA.122.321938. Epub 2023 Mar 6. PMID: 36876496; PMCID: PMC10065965.
Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Nat Metab. 2023 Jan; 5(1):165-181. doi: 10.1038/s42255-022-00722-6. PMID: 36646756; PMCID: PMC9995220.
2022
Ilacqua N, Anastasia I, Aloshyn D, Ghandehari-Alavijeh R, Peluso EA, Brearley-Sholto MC, Pellegrini LV, Raimondi A, de Aguiar Vallim TQ, Pellegrini L. Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis. Biol Direct. 2022 Dec 1; 17(1):37. doi: 10.1186/s13062-022-00344-8. PMID: 36457006; PMCID: PMC9717519.
Moore TM, Cheng L, Wolf DM, Ngo J, Segawa M, Zhu X, Strumwasser AR, Cao Y, Clifford BL, Ma A, Scumpia P, Shirihai OS, Vallim TQA, Laakso M, Lusis AJ, Hevener AL, Zhou Z. Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Nat Commun. 2022 Nov 4; 13(1):6661. doi: 10.1038/s41467-022-34468-2. PMID: 36333379; PMCID: PMC9636263.
O'Callaghan M, Helly F, Tarling E, Keane MP, McCarthy C. Methionine supplementation: potential for improving alveolar macrophage function through reverse cholesterol transport? Eur Respir J. 2022 May 5; 59(5):2102594. doi: 10.1183/13993003.02594-2021. PMID: 34857611.
Doerfler AM, Han J, Jarrett KE, Tang L, Jain A, Saltzman A, De Giorgi M, Chuecos M, Hurley AE, Li A, Morand P, Ayala C, Goodlett DR, Malovannaya A, Martin JF, de Aguiar Vallim TQ, Shroyer N, Lagor WR. Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment. Arterioscler Thromb Vasc Biol. 2022 Apr; 42(4):381-394. doi: 10.1161/ATVBAHA.122.317320. PMID: 35172604; PMCID: PMC8957608.
Yildirim Z, Baboo S, Hamid SM, Dogan AE, Tufanli O, Robichaud S, Emerton C, Diedrich JK, Vatandaslar H, Nikolos F, Gu Y, Iwawaki T, Tarling E, Ouimet M, Nelson DL, Yates JR 3rd, Walter P, Erbay E. Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. EMBO Mol Med. 2022 Apr 7; 14(4):e15344. doi: 10.15252/emmm.202115344. Epub 2022 Feb 22. PMID: 35191199; PMCID: PMC8988208.
De Giorgi M, Jarrett KE, de Aguiar Vallim TQ, Lagor WR. In Vivo Gene Editing in Lipid and Atherosclerosis Research. Methods Mol Biol. 2022; 2419:673-713. doi: 10.1007/978-1-0716-1924-7_42. PMID: 35237996.
Ilacqua N, Anastasia I, Raimondi A, Lemieux P, de Aguiar Vallim TQ, Toth K, Koonin EV, Pellegrini L. A three-organelle complex made by wrappER contacts with peroxisomes and mitochondria responds to liver lipid flux changes. J Cell Sci. 2022 Mar 1;135(5):jcs259091. doi: 10.1242/jcs.259091. Epub 2021 Nov 2. PMID: 34672330; PMCID: PMC8627550.
Mukherjee P, Chattopadhyay A, Grijalva V, Dorreh N, Lagishetty V, Jacobs JP, Clifford BL, Vallim T, Mack JJ, Navab M, Reddy ST, Fogelman AM. Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation. J Lipid Res. 2022 Jan;63(1):100153. doi: 10.1016/j.jlr.2021.100153. Epub 2021 Nov 20. PMID: 34808192; PMCID: PMC8953663.
2021
Ataya A, Knight V, Carey BC, Lee E, Tarling EJ, Wang T. The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review. Front Immunol. 2021 Nov 22; 12:752856. doi: 10.3389/fimmu.2021.752856. PMID: 34880857; PMCID: PMC8647160.
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metab. 2021 Aug 3;33(8):1671-1684.e4. doi: 10.1016/j.cmet.2021.06.012. Epub 2021 Jul 15. PMID: 34270928; PMCID: PMC8353952.
Zhuang A, Calkin AC, Lau S, Kiriazis H, Donner DG, Liu Y, Bond ST, Moody SC, Gould EAM, Colgan TD, Carmona SR, Inouye M, de Aguiar Vallim TQ, Tarling EJ, Quaife-Ryan GA, Hudson JE, Porrello ER, Gregorevic P, Gao XM, Du XJ, McMullen JR, Drew BG. Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner. iScience. 2021 May 13; 24(6):102537. doi: 10.1016/j.isci.2021.102537. PMID: 34142046; PMCID: PMC8184514.
de Aguiar Vallim TQ, Tarling EJ. mInd the gAP: Intestinal Alkaline Phosphatase Puts the Breaks on Atherosclerosis. Circ Res. 2021 May 28; 128(11):1660-1662. doi: 10.1161/CIRCRESAHA.121.319307. Epub 2021 May 27. PMID: 34043422; PMCID: PMC8171811.
von Scheidt M, Zhao Y, de Aguiar Vallim TQ, Che N, Wierer M, Seldin MM, Franzén O, Kurt Z, Pang S, Bongiovanni D, Yamamoto M, Edwards PA, Ruusalepp A, Kovacic JC, Mann M, Björkegren JLM, Lusis AJ, Yang X, Schunkert H. Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation. 2021 May 4;143(18):1809-1823. doi: 10.1161/CIRCULATIONAHA.120.050186. Epub 2021 Feb 25. PMID: 33626882; PMCID: PMC8124091.
Anastasia I, Ilacqua N, Raimondi A, Lemieux P, Ghandehari-Alavijeh R, Faure G, Mekhedov SL, Williams KJ, Caicci F, Valle G, Giacomello M, Quiroga AD, Lehner R, Miksis MJ, Toth K, de Aguiar Vallim TQ, Koonin EV, Scorrano L, Pellegrini L. Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis. Cell Rep. 2021 Mar 16; 34(11):108873. doi: 10.1016/j.celrep.2021.108873. PMID: 33730569.
Bond ST, King EJ, Henstridge DC, Tran A, Moody SC, Yang C, Liu Y, Mellett NA, Nath AP, Inouye M, Tarling EJ, de Aguiar Vallim TQ, Meikle PJ, Calkin AC, Drew BG. Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance. Nat Commun. 2021 Jan 4; 12(1):74. doi: 10.1038/s41467-020-20434-3. PMID: 33397965; PMCID: PMC7782476.
2020
Clifford BL, Jarrett KE, Cheng J, Cheng A, Seldin MM, Morand P, Lee RG, Baldán Á, de Aguiar Vallim TQ, Tarling EJ. GOLIATH regulates LDLR availability and plasma LDL cholesterol levels. bioRxiv. 2020 Dec; 415323; doi: https://doi.org/10.1101/2020.12.09.415323.
Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 Jul;21(7):746-755. doi: 10.1038/s41590-020-0695-4. Epub 2020 Jun 8. PMID: 32514064; PMCID: PMC7778040.
Cheng J, Cheng A, Clifford BL, Wu X, Hedin U, Maegdefessel L, Pamir N, Sallam T, Tarling EJ, de Aguiar Vallim TQ. MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):412-425. doi: 10.1161/ATVBAHA.119.313633. Epub 2019 Dec 19. PMID: 31852219; PMCID: PMC7018399.
Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Büning H, Yang L, Cao H, Jesus DF, Kulkarni RN, Zevnik B, Tröder SE, Knippschild U, Edwards PA, Lee RG, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim TQA, Kornfeld JW. A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism. Nat Commun. 2020 Jan 31; 11(1):644. doi: 10.1038/s41467-020-14323-y. PMID: 32005828; PMCID: PMC6994702.
2019
Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. An integrative systems genetic analysis of mammalian lipid metabolism. Nature. 2019 Mar;567(7747):187-193. doi: 10.1038/s41586-019-0984-y. Epub 2019 Feb 27. PMID: 30814737; PMCID: PMC6656374.
Pamir N, Pan C, Plubell DL, Hutchins PM, Tang C, Wimberger J, Irwin A, Vallim TQA, Heinecke JW, Lusis AJ. Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity. J Lipid Res. 2019 Mar;60(3):594-608. doi: 10.1194/jlr.M090555. Epub 2019 Jan 8. PMID: 30622162; PMCID: PMC6399512.
2018
Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell. 2018 Sep 20;175(1):117-132.e21. doi: 10.1016/j.cell.2018.08.017. Epub 2018 Sep 6. PMID: 30197082; PMCID: PMC6151140.
Tumurkhuu G, Dagvadorj J, Porritt RA, Crother TR, Shimada K, Tarling EJ, Erbay E, Arditi M, Chen S. Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab. 2018 Sep 4;28(3):432-448.e4. doi: 10.1016/j.cmet.2018.05.027. Epub 2018 Jun 21. PMID: 29937375; PMCID: PMC6125162.
McCarthy C, Lee E, Bridges JP, Sallese A, Suzuki T, Woods JC, Bartholmai BJ, Wang T, Chalk C, Carey BC, Arumugam P, Shima K, Tarling EJ, Trapnell BC. Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nat Commun. 2018 Aug 7;9(1):3127. doi: 10.1038/s41467-018-05491-z. PMID: 30087322; PMCID: PMC6081448.
2017
Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017 Nov 20;8(1):1620. doi: 10.1038/s41467-017-01741-8. PMID: 29158473; PMCID: PMC5696341.
Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Elife. 2017 Oct 25;6:e28766. doi: 10.7554/eLife.28766. PMID: 29068315; PMCID: PMC5656429.
Rong X, Wang B, Palladino EN, de Aguiar Vallim TQ, Ford DA, Tontonoz P. ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017 Oct 2;127(10):3640-3651. doi: 10.1172/JCI93616. Epub 2017 Aug 28. PMID: 28846071; PMCID: PMC5617651.
Tarling EJ, Clifford BL, Cheng J, Morand P, Cheng A, Lester E, Sallam T, Turner M, de Aguiar Vallim TQ. RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism. J Clin Invest. 2017 Oct 2;127(10):3741-3754. doi: 10.1172/JCI94029. Epub 2017 Sep 11. PMID: 28891815; PMCID: PMC5617661.
de Aguiar Vallim TQ, Lee E, Merriott DJ, Goulbourne CN, Cheng J, Cheng A, Gonen A, Allen RM, Palladino END, Ford DA, Wang T, Baldán Á, Tarling EJ. ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res. 2017 May;58(5):941-954. doi: 10.1194/jlr.M075101. Epub 2017 Mar 6. PMID: 28264879; PMCID: PMC5408613.
2016
Baldán Á, de Aguiar Vallim TQ. miRNAs and High-Density Lipoprotein metabolism. Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2053-2061. doi: 10.1016/j.bbalip.2016.01.021. Epub 2016 Feb 9. PMID: 26869447; PMCID: PMC4980286.
Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13;8(334):334ra54. doi: 10.1126/scitranslmed.aad3815. PMID: 27075628; PMCID: PMC4934679.
Zhang H, de Aguiar Vallim TQ, Martel C; Early Career Committee. Translational and Therapeutic Approaches to the Understanding and Treatment of Dyslipidemia. Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):e56-61. doi: 10.1161/ATVBAHA.116.307808. PMID: 27335468; PMCID: PMC4920133.
Tarling EJ, Edwards PA. Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report. Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1323-7. doi: 10.1161/ATVBAHA.116.307414. Epub 2016 May 26. PMID: 27230131; PMCID: PMC4919203.
2015
York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10. PMID: 26686653; PMCID: PMC4783382.
Wei H, Tarling EJ, McMillen TS, Tang C, LeBoeuf RC. ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction. J Lipid Res. 2015 Dec;56(12):2337-47. doi: 10.1194/jlr.M063354. Epub 2015 Oct 21. PMID: 26489644; PMCID: PMC4655989.
Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 2015 Jul 14;4:e08009. doi: 10.7554/eLife.08009. PMID: 26173179; PMCID: PMC4517437.
Tarling EJ, Ahn H, de Aguiar Vallim TQ. The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):787-95. doi: 10.1161/ATVBAHA.114.304179. Epub 2015 Jan 15. PMID: 25593129; PMCID: PMC4376635.
de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 3;21(2):298-311. doi: 10.1016/j.cmet.2015.01.007. Erratum in: Cell Metab. 2016 Mar 8;23(3):563. PMID: 25651182; PMCID: PMC4317590.
2014
Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol. 2014 Dec 1;193(11):5637-48. doi: 10.4049/jimmunol.1400606. Epub 2014 Oct 22. PMID: 25339664; PMCID: PMC4239162.
2013
Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013 Nov 5;18(5):685-97. doi: 10.1016/j.cmet.2013.10.002. PMID: 24206663; PMCID: PMC3889491.
Tarling EJ, de Aguiar Vallim TQ, Edwards PA. Role of ABC transporters in lipid transport and human disease. Trends Endocrinol Metab. 2013 Jul;24(7):342-50. doi: 10.1016/j.tem.2013.01.006. Epub 2013 Feb 14. PMID: 23415156; PMCID: PMC3659191.
de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res. 2013 Jun 7;112(12):1602-12. doi: 10.1161/CIRCRESAHA.112.300648. Epub 2013 Mar 21. PMID: 23519696; PMCID: PMC3995747.
de Aguiar Vallim TQ, Tarling EJ, Edwards PA. Pleiotropic roles of bile acids in metabolism. Cell Metab. 2013 May 7;17(5):657-69. doi: 10.1016/j.cmet.2013.03.013. Epub 2013 Apr 18. PMID: 23602448; PMCID: PMC3654004.
Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. Response to Pomozi et al's research commentary. Circ Res. 2013 May 24;112(11):e152-3. doi: 10.1161/CIRCRESAHA.113.301666. Epub 2013 Apr 26. PMID: 23625949; PMCID: PMC3999040.
Tarling EJ. Expanding roles of ABCG1 and sterol transport. Curr Opin Lipidol. 2013 Apr;24(2):138-46. doi: 10.1097/MOL.0b013e32835da122. PMID: 23340182.
Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013 Jan 8;17(1):49-60. doi: 10.1016/j.cmet.2012.12.011. PMID: 23312283; PMCID: PMC3771112.
2012
Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. ABCC6 localizes to the mitochondria-associated membrane. Circ Res. 2012 Aug 17;111(5):516-20. doi: 10.1161/CIRCRESAHA.112.276667. Epub 2012 Jul 17. PMID: 22811557; PMCID: PMC3540978.
2011
Tarling EJ, Edwards PA. ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19719-24. doi: 10.1073/pnas.1113021108. Epub 2011 Nov 17. PMID: 22095132; PMCID: PMC3241749.
2010
Jiang YJ, Lu B, Tarling EJ, Kim P, Man MQ, Crumrine D, Edwards PA, Elias PM, Feingold KR. Regulation of ABCG1 expression in human keratinocytes and murine epidermis. J Lipid Res. 2010 Nov;51(11):3185-95. doi: 10.1194/jlr.M006445. Epub 2010 Aug 1. PMID: 20675829; PMCID: PMC2952559.
Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA. Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Mol Endocrinol. 2010 Aug;24(8):1626-36. doi: 10.1210/me.2010-0117. Epub 2010 Jun 23. PMID: 20573685; PMCID: PMC2940469.
Tarling EJ, Bojanic DD, Tangirala RK, Wang X, Lovgren-Sandblom A, Lusis AJ, Bjorkhem I, Edwards PA. Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1174-80. doi: 10.1161/ATVBAHA.110.205617. Epub 2010 Mar 18. PMID: 20299684; PMCID: PMC2881948.
2009
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Tarr PT, Tarling EJ, Bojanic DD, Edwards PA, Baldán A. Emerging new paradigms for ABCG transporters. Biochim Biophys Acta. 2009 Jul;1791(7):584-93. doi: 10.1016/j.bbalip.2009.01.007. Epub 2009 Jan 22. PMID: 19416657; PMCID: PMC2698934.
Tarling EJ, Ryan KJ, Bennett AJ, Salter AM. Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high-fat diets. Br J Nutr. 2009 Jun;101(11):1630-8. doi: 10.1017/S0007114508118785. Epub 2008 Nov 5. PMID: 18983716; PMCID: PMC2695940.
2007
2005
O'Sullivan SE, Tarling EJ, Bennett AJ, Kendall DA, Randall MD. Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma. Biochem Biophys Res Commun. 2005 Nov 25;337(3):824-31. doi: 10.1016/j.bbrc.2005.09.121. Epub 2005 Sep 29. PMID: 16213464.